Alternate proteins from the same gene contribute differently to health and rare disease

alternate-proteins-from-the-same-gene-contribute-differently-to-health-and-rare-disease

Around 25 million Americans have rare genetic diseases, and many of them struggle with not only a lack of effective treatments, but also a lack of good information about their disease. Clinicians may not know what causes a patient’s symptoms, know how their disease will progress, or even have a clear diagnosis. Researchers have looked to the human genome for answers, and many disease-causing genetic mutations have been identified, but as many as 70 percent of patients still lack a clear genetic explanation.

In a paper published in Molecular Cell on Nov. 7, Whitehead Institute for Biomedical Research member Iain Cheeseman, graduate student Jimmy Ly, and colleagues propose that researchers and clinicians may be able to get more information from patients’ genomes by looking at them in a different way.

The common wisdom is that each gene codes for one protein.

 » Read More

MIT engineers design an aerial microrobot that can fly as fast as a bumblebee

mit-engineers-design-an-aerial-microrobot-that-can-fly-as-fast-as-a-bumblebee

In the future, tiny flying robots could be deployed to aid in the search for survivors trapped beneath the rubble after a devastating earthquake. Like real insects, these robots could flit through tight spaces larger robots can’t reach, while simultaneously dodging stationary obstacles and pieces of falling rubble.

So far, aerial microrobots have only been able to fly slowly along smooth trajectories, far from the swift, agile flight of real insects — until now.

MIT researchers have demonstrated aerial microrobots that can fly with speed and agility that is comparable to their biological counterparts. A collaborative team designed a new AI-based controller for the robotic bug that enabled it to follow gymnastic flight paths, such as executing continuous body flips.

With a two-part control scheme that combines high performance with computational efficiency, the robot’s speed and acceleration increased by about 450 percent and 250 percent,

 » Read More

MIT researchers demonstrate ship hull modifications to cut fuel use

mit-researchers-demonstrate-ship-hull-modifications-to-cut-fuel-use

Researchers at MIT have demonstrated that wedge-shaped vortex generators attached to a ship’s hull can reduce drag by up to 7.5 percent, which reduces overall ship emissions and fuel expenses. The paper, “Net Drag Reduction in High Block Coefficient Ships and Vehicles Using Vortex Generators,” was presented at the Society of Naval Architects and Marine Engineers 2025 Maritime Convention in Norfolk, Virginia.

The work offers a promising path toward decarbonization, addressing the pressing need to meet the International Maritime Organization (IMO) goal to reduce carbon intensity of international shipping by at least 40 percent by 2030, compared to 2008 levels. Achieving such ambitious emissions reduction will require a coordinated approach, employing multiple methods, from redesigning ship hulls, propellers, and engines to using novel fuels and operational methods.

The researchers — José del Águila Ferrandis, Jack Kimmeth, and Michael Triantafyllou of MIT Sea Grant and the Department of Mechanical Engineering,

 » Read More

Apple to refuse Indian government order to pre-install state security app on iPhones

apple-to-refuse-indian-government-order-to-pre-install-state-security-app-on-iphones

The Indian government issued a mandate that intends to force smartphone companies like Apple and Samsung to preinstall a state-run security app called ‘Sanchar Saathi’ on phones sold in the region. The companies have 90 days to comply.

But Reuters reports Apple intends to refuse the order and will not install the app on iPhones. The company will tell the Indian government that it does not comply with such orders in any market in which it participates, due to the associated security and privacy risks.

more…  » Read More

MagSafe Monday: This new hub is basically a Swiss Army knife for your iPhone or Mac

magsafe-monday:-this-new-hub-is-basically-a-swiss-army-knife-for-your-iphone-or-mac

There has always been this tension with Apple’s devices. Some people want no ports, and some people want them all. I can argue both sides, but the trend is clearly moving toward fewer ports. Satechi’s new MagSafe 7-in-1 hub is one of the first accessories I have used that actually fills that gap in a smart way. It gives the iPhone some of the flexibility of a Mac without adding much clutter or complexity, but can also serve as a portable hub for your Mac as well.

more…  » Read More